Use Warning/Monitor. Ethinyl estradiol may well inhibit the clearance of benzodiazepines that undertake oxidation, thereby escalating serum concentrations of concomitantly administered benzodiazepines.
cenobamate will improve the stage or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep track of Closely. Look at a dose reduction of CYP2C19 substrates, as clinically correct, when made use of concomitantly with cenobamate.
Steer clear of coadministration of delicate CYP3A4 substrates with ivosidenib or switch with alternate therapies. If coadministration is unavoidable, keep an eye on patients for lack of therapeutic result of those drugs.
cannabidiol will improve the degree or influence of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Carefully. Contemplate decreasing the dose of sensitive CYP2C19 substrates, as clinically acceptable, when coadministered with cannabidiol.
Getting VALIUM with sure other medicines might cause Unintended effects or affect how very well VALIUM or one other medicines function. Will not commence or prevent other medicines with no speaking with your healthcare supplier.
quinupristin/dalfopristin will raise the amount or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Before you consider VALIUM, inform your healthcare provider about all of your clinical situations, together with if you: have or have had depression, temper difficulties, or suicidal views or website conduct
phenytoin will minimize the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
iloperidone will increase amounts of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Iloperidone is really a time-dependent CYP3A inhibitor and could produce greater plasma amounts of medicines predominantly eradicated by CYP3A4.
Coadministration of encorafenib with delicate CYP3A4 substrates may end in enhanced toxicity or decreased efficacy of those agents.
lemborexant, diazepam. Both will increase results of one other by sedation. Modify Therapy/Observe Closely. Dosage adjustment could possibly be essential if lemborexant is coadministered with other CNS depressants simply because of doubtless additive consequences.
The moment acute symptomatology has long been properly managed with diazepam injection, the affected individual could be placed on oral therapy if additional therapy needed
isoniazid will enhance the level or impact of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Diazepam can be absorbed into plastics, so liquid preparations are not retained in plastic bottles or syringes, and so on. Therefore, it could leach into your plastic bags and tubing employed for intravenous infusions.